Sourcery

USV’s new $900 million fund marks a major shift for a firm known for staying intentionally small. Fred Wilson, Rebecca Kaden, and Mike Mignano explain why AI is changing venture economics, what kinds of companies they expect next, and why they think this moment resembles the internet in 2003.

AI agents, not humans, may become the primary users of internet products and payment systems. John Collison explains why Stripe is reworking infrastructure for that shift, how agents could change commerce and product discovery, and why the same trend may intensify cybersecurity risks.

AI training and deployment in 2026 is the focus here, with Turing CEO Jonathan Siddharth arguing that enterprises need practical systems more than frontier-only models. The conversation spans agent training, open-weight model progress, enterprise AI strategy, safety, and the pace toward superintelligence.

Healthcare and fintech investor Annie Lamont discusses where AI is changing drug discovery, care delivery, and healthcare administration. She also digs into China’s growing role in life sciences, shifting healthcare M&A, and why only a small slice of AI companies merit their valuations.

This episode looks at silicon photonics and optical interconnects as a critical constraint in scaling AI infrastructure. Herwig Van Hove and Yannick De Koninck discuss why copper is hitting limits, what NVIDIA taught Yannick about photonics, and why Europe could play a major manufacturing role.