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Latent Space: The AI Engineer Podcast
Podcast

Latent Space: The AI Engineer Podcast

Latent.Space

221 episodes · Technology, Science

The podcast by and for AI Engineers! In 2025, over 10 million readers and listeners came to Latent Space to hear about news, papers and interviews in Software 3.0. We cover Foundation Models changing every domain in Code Generation, Multimodality, AI Agents, GPU Infra and more, directly from the founders, builders, and thinkers involved in pushing the cutting edge. Striving to give you both the definitive take on the Current Thing down to the first introduction to the tech you'll be using in the next 3 months! We break news and exclusive interviews from OpenAI, Anthropic, Gemini, Meta (Soumith Chintala), Sierra (Bret Taylor), tiny (George Hotz), Databricks/MosaicML (Jon Frankle), Modular (Chris Lattner), Answer.ai (Jeremy Howard), et al. Full show notes always on https://latent.space Sponsorship and business inquiries: business@latent.space www.latent.space (https://www.latent.space?utm_medium=podcast)

Episodes

🔬“We have foundation models for language, not for physics” — Anima Anandkumar, Bren Professor of Computing
🔬“We have foundation models for language, not for physics” — Anima Anandkumar, Bren Professor of Computing
Aug 26, 2026 · 1h 23m
Simulation: the new Scaling Law — Joon Sung Park, Simile AI
Simulation: the new Scaling Law — Joon Sung Park, Simile AI
Aug 21, 2026 · 1h 9m
🔬The BioAI Phase Shift - Matthew McPartlon & Neil Patil, Chai Discovery
🔬The BioAI Phase Shift - Matthew McPartlon & Neil Patil, Chai Discovery
Aug 11, 2026 · 1h 35m
The Inference Engineering Masterclass — Philip Kiely & Ali Taha, Baseten
The Inference Engineering Masterclass — Philip Kiely & Ali Taha, Baseten
Aug 3, 2026 · 1h 41m
Codex from 0 to 10M Users: Building ChatGPT Work — Akshay Nathan, OpenAI
Codex from 0 to 10M Users: Building ChatGPT Work — Akshay Nathan, OpenAI
Jul 28, 2026 · 1h 9m
Inside the Model Factory — Eiso Kant, Poolside AI
Inside the Model Factory — Eiso Kant, Poolside AI
Jul 23, 2026 · 1h 54m
🔬Causal Models Need Causal Data - Xaira’s X-Cell model for Drug Discovery (Bo Wang & Ci Chu, Chief Discovery Officer & Chief AI Scientist)
🔬Causal Models Need Causal Data - Xaira’s X-Cell model for Drug Discovery (Bo Wang & Ci Chu, Chief Discovery Officer & Chief AI Scientist)
Jul 21, 2026 · 1h 29m
🔬 The Lab of the Future Should Feel Like a Data Center — Andy Beam & Rafa Gómez-Bombarelli, Lila Sciences
🔬 The Lab of the Future Should Feel Like a Data Center — Andy Beam & Rafa Gómez-Bombarelli, Lila Sciences
Jul 16, 2026 · 1h 41m
Why AI Infrastructure must evolve for Agent Experience — Akshat Bubna, Modal CTO
Why AI Infrastructure must evolve for Agent Experience — Akshat Bubna, Modal CTO
Jul 8, 2026 · 57 min
🔬 The Coolest Diffusion Research Isn't in LLMs — Evan Feinberg & Sergey Edunov, Genesis Molecular AI
🔬 The Coolest Diffusion Research Isn't in LLMs — Evan Feinberg & Sergey Edunov, Genesis Molecular AI
Jul 1, 2026 · 1h 48m
Why the Frontier Ecosystem must be Open — Matei Zaharia and Reynold Xin, Databricks
Why the Frontier Ecosystem must be Open — Matei Zaharia and Reynold Xin, Databricks
Jun 24, 2026 · 1h 8m
Red-Teaming after Mythos — Zico Kolter & Matt Fredrikson, Gray Swan
Red-Teaming after Mythos — Zico Kolter & Matt Fredrikson, Gray Swan
Jun 22, 2026 · 1h 6m
The Professor of Outputmaxxing — Anjney Midha, AMP
The Professor of Outputmaxxing — Anjney Midha, AMP
Jun 18, 2026 · 59 min
🔬 The Self-Driving Lab — Joseph Krause, Radical AI
🔬 The Self-Driving Lab — Joseph Krause, Radical AI
Jun 17, 2026 · 1h 16m
Reality: The Final Eval — Lukas Petersson and Axel Backlund of Andon Labs
Reality: The Final Eval — Lukas Petersson and Axel Backlund of Andon Labs
Jun 4, 2026 · 1h 15m
🔬Scaling Past Informal AI - Carina Hong, Axiom Math
🔬Scaling Past Informal AI - Carina Hong, Axiom Math
Jun 3, 2026 · 1h 33m
⚡️Satya Nadella: No Priors x Latent Space Crossover Special at Microsoft Build
⚡️Satya Nadella: No Priors x Latent Space Crossover Special at Microsoft Build
Jun 3, 2026 · 38 min
GitHub's plan for Agents — Kyle Daigle, GitHub
GitHub's plan for Agents — Kyle Daigle, GitHub
Jun 2, 2026 · 1h 23m
Why Video Agent models are next — Ethan He, xAI Grok Imagine
Why Video Agent models are next — Ethan He, xAI Grok Imagine
Jun 1, 2026 · 1h 43m
The Age of Async Agents — Cognition's Walden Yan & OpenInspect's Cole Murray
The Age of Async Agents — Cognition's Walden Yan & OpenInspect's Cole Murray
May 28, 2026 · 1h 8m
🔬ESM: The Bitter Lesson is Coming for Proteins - Alex Rives, BioHub
🔬ESM: The Bitter Lesson is Coming for Proteins - Alex Rives, BioHub
May 27, 2026 · 1h 10m
Giving Agents Computers — Ivan Burazin, Daytona
Giving Agents Computers — Ivan Burazin, Daytona
May 21, 2026 · 1h 10m
Railway: The Agent-Native Cloud — Jake Cooper
Railway: The Agent-Native Cloud — Jake Cooper
May 20, 2026 · 1h 28m
The Autonomous Drone Tech Stack & Economics of Drones — Yaroslav Azhnyuk, The Fourth Law & Guest Host Noah Smith, Noahpinion
The Autonomous Drone Tech Stack & Economics of Drones — Yaroslav Azhnyuk, The Fourth Law & Guest Host Noah Smith, Noahpinion
May 18, 2026 · 1h 59m
AI-Native Healthcare: 100M Doctor Visits, 10–20 Hours Saved, Prior Auth in Minutes — Janie Lee & Chai Asawa, Abridge
AI-Native Healthcare: 100M Doctor Visits, 10–20 Hours Saved, Prior Auth in Minutes — Janie Lee & Chai Asawa, Abridge
May 14, 2026 · 1h 5m
🔬Doing Vibe Physics — Alex Lupsasca, OpenAI
🔬Doing Vibe Physics — Alex Lupsasca, OpenAI
May 5, 2026 · 1h 31m
Physical AI that Moves the World — Qasar Younis & Peter Ludwig, Applied Intuition
Physical AI that Moves the World — Qasar Younis & Peter Ludwig, Applied Intuition
Apr 27, 2026 · 1h 12m
AIE Europe Debrief + Agent Labs Thesis: Unsupervised Learning x Latent Space Crossover Special (2026)
AIE Europe Debrief + Agent Labs Thesis: Unsupervised Learning x Latent Space Crossover Special (2026)
Apr 23, 2026 · 54 min
Shopify’s AI Phase Transition: 2026 Usage Explosion, Unlimited Opus-4.6 Token Budget, Tangle, Tangent, SimGym — with Mikhail Parakhin, Shopify CTO
Shopify’s AI Phase Transition: 2026 Usage Explosion, Unlimited Opus-4.6 Token Budget, Tangle, Tangent, SimGym — with Mikhail Parakhin, Shopify CTO
Apr 22, 2026 · 1h 12m
🔬 Training Transformers to solve 95% failure rate of Cancer Trials — Ron Alfa & Daniel Bear, Noetik
🔬 Training Transformers to solve 95% failure rate of Cancer Trials — Ron Alfa & Daniel Bear, Noetik
Apr 20, 2026 · 1h 25m
Notion’s Token Town: 5 Rebuilds, 100+ Tools, MCP vs CLIs and the Software Factory Future — Simon Last & Sarah Sachs of Notion
Notion’s Token Town: 5 Rebuilds, 100+ Tools, MCP vs CLIs and the Software Factory Future — Simon Last & Sarah Sachs of Notion
Apr 15, 2026 · 1h 17m
Extreme Harness Engineering for Token Billionaires: 1M LOC, 1B toks/day, 0% human code, 0% human review — Ryan Lopopolo, OpenAI Frontier & Symphony
Extreme Harness Engineering for Token Billionaires: 1M LOC, 1B toks/day, 0% human code, 0% human review — Ryan Lopopolo, OpenAI Frontier & Symphony
Apr 7, 2026 · 1h 12m
Marc Andreessen introspects on The Death of the Browser, Pi + OpenClaw, and Why "This Time Is Different"
Marc Andreessen introspects on The Death of the Browser, Pi + OpenClaw, and Why "This Time Is Different"
Apr 3, 2026 · 1h 16m
Moonlake: Causal World Models should be Multimodal, Interactive, and Efficient — with Chris Manning and Fan-yun Sun
Moonlake: Causal World Models should be Multimodal, Interactive, and Efficient — with Chris Manning and Fan-yun Sun
Apr 2, 2026 · 1h 6m
Mistral: Voxtral TTS, Forge, Leanstral, & what's next for Mistral 4 — w/ Pavan Kumar Reddy & Guillaume Lample
Mistral: Voxtral TTS, Forge, Leanstral, & what's next for Mistral 4 — w/ Pavan Kumar Reddy & Guillaume Lample
Mar 30, 2026 · 48 min
🔬Why There Is No "AlphaFold for Materials" — AI for Materials Discovery with Heather Kulik
🔬Why There Is No "AlphaFold for Materials" — AI for Materials Discovery with Heather Kulik
Mar 24, 2026 · 35 min
Dreamer: the Personal Agent OS — David Singleton
Dreamer: the Personal Agent OS — David Singleton
Mar 20, 2026 · 1h 3m
Why Anthropic Thinks AI Should Have Its Own Computer — Felix Rieseberg of Claude Cowork & Claude Code Desktop
Why Anthropic Thinks AI Should Have Its Own Computer — Felix Rieseberg of Claude Cowork & Claude Code Desktop
Mar 17, 2026 · 1h 26m
Retrieval After RAG: Hybrid Search, Agents, and Database Design — Simon Hørup Eskildsen of Turbopuffer
Retrieval After RAG: Hybrid Search, Agents, and Database Design — Simon Hørup Eskildsen of Turbopuffer
Mar 12, 2026 · 1h 0m
NVIDIA's AI Engineers: Agent Inference at Planetary Scale and "Speed of Light" — Nader Khalil (Brev), Kyle Kranen (Dynamo)
NVIDIA's AI Engineers: Agent Inference at Planetary Scale and "Speed of Light" — Nader Khalil (Brev), Kyle Kranen (Dynamo)
Mar 10, 2026 · 1h 23m
Cursor's Third Era: Cloud Agents
Cursor's Third Era: Cloud Agents
Mar 6, 2026 · 1h 6m
Every Agent Needs a Box — Aaron Levie, Box
Every Agent Needs a Box — Aaron Levie, Box
Mar 5, 2026 · 1h 16m
METR’s Joel Becker on exponential Time Horizon Evals, Threat Models, and the Limits of AI Productivity
METR’s Joel Becker on exponential Time Horizon Evals, Threat Models, and the Limits of AI Productivity
Feb 27, 2026 · 56 min
[LIVE] Anthropic Distillation & How Models Cheat (SWE-Bench Dead) | Nathan Lambert & Sebastian Raschka
[LIVE] Anthropic Distillation & How Models Cheat (SWE-Bench Dead) | Nathan Lambert & Sebastian Raschka
Feb 26, 2026 · 52 min
🔬Searching the Space of All Possible Materials — Prof. Max Welling, CuspAI
🔬Searching the Space of All Possible Materials — Prof. Max Welling, CuspAI
Feb 25, 2026 · 33 min
Claude Code for Finance + The Global Memory Shortage: Doug O'Laughlin, SemiAnalysis
Claude Code for Finance + The Global Memory Shortage: Doug O'Laughlin, SemiAnalysis
Feb 24, 2026 · 2h 4m
⚡️The End of SWE-Bench Verified — Mia Glaese & Olivia Watkins, OpenAI Frontier Evals & Human Data
⚡️The End of SWE-Bench Verified — Mia Glaese & Olivia Watkins, OpenAI Frontier Evals & Human Data
Feb 23, 2026 · 26 min
Bitter Lessons in Venture vs Growth: Anthropic vs OpenAI, Noam Shazeer, World Labs, Thinking Machines, Cursor, ASIC Economics — Martin Casado & Sarah Wang of a16z
Bitter Lessons in Venture vs Growth: Anthropic vs OpenAI, Noam Shazeer, World Labs, Thinking Machines, Cursor, ASIC Economics — Martin Casado & Sarah Wang of a16z
Feb 19, 2026 · 55 min
Owning the AI Pareto Frontier — Jeff Dean
Owning the AI Pareto Frontier — Jeff Dean
Feb 12, 2026 · 1h 23m
🔬Beyond AlphaFold: How Boltz is Open-Sourcing the Future of Drug Discovery
🔬Beyond AlphaFold: How Boltz is Open-Sourcing the Future of Drug Discovery
Feb 12, 2026 · 1h 21m