All-In with Chamath, Jason, Sacks & Friedberg

Martin Shkreli joins the Besties for a wide-ranging conversation on quantum computing, pharmaceutical pricing, AI-driven drug discovery, and the personal lessons he says prison taught him. The episode mixes market bets, biotech contrarianism, and a more reflective discussion about brilliance, rule-breaking, and the gifted-kid trap.

AI consciousness leads the conversation, with a debate over whether Claude might be conscious and what model welfare could mean. The episode then shifts to OpenAI's controversial math breakthroughs, unrest in France, bond-market pressure, and a grab bag of late-show tech questions.

Trump’s Super Intelligence Summit leads this episode, with a behind-the-scenes discussion of how an AI safety accord was created and signed. The conversation then widens to cybersecurity, data-center national security, fresh GDP and jobs data, and a look ahead to the midterms and 2028.

Jake Paul and The Chainsmokers join the conversation to talk about turning attention into businesses and investing. The episode moves from boxing and audience-building to celebrity-backed dealmaking, politics, and signs of venture bubble behavior.

Daniel Ek discusses building Spotify to fight piracy, then pivots to Neko Health’s bet on earlier disease detection and a $499 body scan. The conversation also digs into AI’s upside, open versus closed models, compute regulation, and podcasting’s open standards.