From First Principles is a fast, funny, and rigorous breakdown of the biggest science stories of the week, hosted by Lester Nare and physicist Krishna Choudhary, PhD. We go past headlines into the actual mechanics: what happened, why it matters, and what everyone’s missing. Expect physics, space, AI, energy, biotech, and the occasional “wait… is that real?” story. If you’re curious, skeptical, and you like learning in public — you’re in the right place.
What this show covers
ultrasoundbiomedical engineeringcancer treatmenthistotripsymedical innovationrobotic labsanimal behaviorAI in scienceprotein designepilepsy
What listeners will find here
Sound waves that can destroy tumors without an incision
Histotripsy turns focused ultrasound into tiny bubbles that mechanically break apart tissue, offering a noninvasive way to treat tumors. Dr. Zhen Xu traces the accidental discovery, the physics behind it, and how liver cancer treatment moved from lab surprise to clinical reality.
AI leaves the chatbot and enters the lab, but proof still takes time
What happens when AI gets a lab? The episode follows three cases: orangutan mothers shaping infant play, epilepsy patients helping train seizure models, and AI-designed protein binders that still need real-world validation.
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