Artificial intelligence is changing everything from art to enterprise IT, and a16z is watching all of it with a close eye. This podcast features discussions with leading AI engineers, founders, and experts, as well as our general partners, about where the technology and industry are heading.
What this show covers
open-weight modelsagent workflowssearch infrastructureAI agentsAI-native productsretrievalinferenceAI infrastructureopen-source AIvLLMscaling lawsAI researchautomated engineeringself-improving systemsscientific discovery
What listeners will find here
Why AI agents need a different kind of search
Search for AI agents is the focus of Sarah Wang’s conversation with Exa CEO Will Bryk. They explore why traditional search falls short for autonomous systems, how retrieval and agent workflows change the problem, and why search could become core infrastructure for the agent economy.
Why vLLM and open-source inference are becoming core AI infrastructure
Open-source inference is the focus here, with Simon Mo joining Elena Burger and Matt Bornstein to discuss vLLM’s rise and why it matters. The episode looks at how open-weight models, infrastructure control, licensing, and economics are reshaping the AI stack.
Can AI help invent the next generation of AI?
Self-accelerating AI is the focus as Mirendil cofounders Behnam Neyshabur and Harsh Mehta discuss systems that can contribute to their own development. The episode looks at AI research, scaling laws, automated engineering, and why faster scientific progress may be AI’s most important application.
Why open-weight image models could reshape AI design tools
Image generation, design workflows, and creative control are at the center of this conversation with Ideogram CEO Mohammad Norouzi. It explores open-weight models, text and layout generation, and how AI design tools may evolve as creators and enterprises demand more controllable outputs.
AI Can Now Exploit Bugs, Not Just Find Them
AI-powered hacking is pushing cybersecurity into a new phase where models can move from vulnerability discovery to exploitation. Joel De La Garza talks with Dylan Ayrey and Feross Aboukhadijeh about supply chain risk, leaked credentials, zero-days, and how defenders need to adapt fast.
Episodes
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